The iconic horror movie Scream franchise is back — and starring original star Neve Campbell as traumatized and complicated Sidney Prescott. \n\nThe fifth film in the Scream series will focus on Neve’s character heading back to her hometown where the horror all began. Courteney Cox and David Arquette will also be making their big returns.However, some actors from the original movie won't be coming back. Keep reading to see what some of the most memorable cast members from the franchise have been doing since being terrorized by the infamous Ghostface.Neve Campbell (Sidney Prescott)Neve Campbell played the protagonist Sidney Prescott who was constantly being hunted by the Ghostface killer. Since her time playing Sidney, she has starred in other films like Wild Things, 54, Skyscraper, and Castle in the Ground. \n\nShe also received rave reviews as political consultant LeAnn Harvey on Netflix’s House of Cards.Courteney Cox (Gale Weathers)While best known for playing Monica Geller on Friends, Courteney Cox also made a name for herself playing nosey, determined reporter and author Gale Weathers in the Scream franchise. \n\nCourteney married her Scream co-star, David Arquette, in 1999, and welcomed daughter Coco together before their divorce in 2013. Courteney also worked on the series Cougar Town from 2009 to 2015.David Arquette (Dewey Riley)David Arquette played the dimwitted but brave Sheriff Dewey Riley who was a hero throughout the series as he continually saved Sidney Prescott as well as many other characters. \n\nSince Scream, David has produced TV shows like Cougar Town and established a production company, Coquette, with his now ex-wife Courteney. He also starred in a documentary about his life as a professional wrestler called You Cannot Kill David Arquette.Drew Barrymore (Casey Becker)Drew Barrymore was already a household name when she appeared in Scream in 1996. Since then, she has appeared in several blockbuster movies including Charlie's Angels, He's Just Not That Into You, and 50 First Dates. \n\nCurrently, she is the host of her own daytime talk show and is a proud mom to daughters Olive and Frankie. She also launched her own beauty collection, Flower Beauty.Skeet Ulrich (Billy Loomis)(Spoiler alert!) Skeet played the very first killer revealed in the Scream franchise. Playing Billy, Sidney’s troubled boyfriend, he was set on getting revenge on Sidney for her mother's affair with his married father. \n\nSince his stint as the killer in Scream, Skeet has starred on shows like Jericho and Law & Order, though he is probably most known for playing Jughead's father on Riverdale.Jamie Kennedy (Randy Meeks)Jamie Kennedy played nerdy but quick Randy Meeks who worked at the video store and had a huge crush on Sidney. While Randy didn’t make it past Scream 2, he did help many other characters survive Ghostface. \n\nPost-Scream, the actor launched his own practical joke reality show called The Jamie Kennedy Experiment and also starred in movies and TV shows like Malibu's Most Wanted and Ghost Whisperer. As a voiceover actor, Jamie has voiced characters on King of the Hill and The Cleveland Show, among others.Rose McGowan (Tatum Riley)In Scream, Rose played popular high school senior Tatum, who is Dewey's little sister and Sidney's BFF. Since that role, Rose went on to have a successful acting career starring in movies and TV shows such as Charmed, Nip/Tuck, and Grindhouse.\n\nMore recently, Rose has been one of the most outspoken advocates in the #MeToo movement, speaking out against Harvey Weinstein and other predators in Hollywood.Matthew Lillard (Stu Macher)In Scream, Matthew Lillard starred as Stu, Billy's very naive best friend. Following the role, Matthew has gone on to act in shows and movies such as Scooby-Doo!, The Good Wife, and Good Girls.Liev Schreiber (Cotton Weary)Liev Schreiber played Cotton Weary, a character accused of a murder he didn’t commit and often viewed as a suspect who could potentially be the man behind Ghostface. While he only appeared on screen in the first movie, Liev went on to appear as a main character in Scream 2 and Scream 3. \n\nAlong with Scream, Liev has also starred in several major movies including The Sum of All Fears, X-Men Origins: Wolverine, and Spotlight (2015). \n\nIn 2005, he won a Tony for his performance in Glengarry Glen Ross. However, he is most known for playing the lead role on Ray Donovan.Roger L. Jackson (Ghostface)The voice behind Ghostface is Roger L. Jackson, who also voiced the killer in the Scream TV spinoff series. \n\nYou might also recognize Roger's voice in several popular video games including Final Fantasy X and Zone of the Enders. He also plays Mr. Mucus in Mucinex ads.